Table 2.

Trimetazidine and CoQ10 enhanced nuclear Nrf2 expression and suppressed the release of cyto-c into cytosol in cisplatin-treated cells

Factor	Control	Cisplatin	Cisplatin+TMZ	Cisplatin+CoQ10	Cisplatin+TMZ+CoQ10
Nrf2/Lamin A	1±0.17	0.41±0.09***	0.6±0.07#	0.63±0.1#	0.87±0.06###$
Cyto-c/GAPDH	1±0.29	17.55±2.94***	10.76±1.35##	9.65±1.78##	6.71±1.02###$
Nrf2/GAPDH	1±0.15	1.23±0.12	1±0.16	1.06±0.07	0.91±0.19
Cyto-c/COX IV	1±0.22	0.24±0.07***	0.47±0.05#	0.56±0.11##	0.65±0.12###$

^***P<0.001 as compared with control;

^#P<0.05,

^##P<0.01, and

^###P<0.001 as compared with cisplatin-treated cells;

^$P<0.05 as compared with TMZ or CoQ10-pretreated cells.

TMZ - trimetazidine; CoQ10 - coenzyme Q10