Table 4.
Summary of All Significant Variables Found in Irritable Bowel Syndrome Patients
| IBS-C (n = 33) | IBS-D (n = 21) | IBS-M (n = 5) | ||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Male (n = 6) | Female (n = 27) | Male (n = 12) | Female (n = 9) | Male (n = 2) | Female (n = 3) | |
| Neurotrophic factors | ||||||
| TRPV1 | ↑ | - | - | |||
| NGF | ↑ | - | - | |||
| GDNF | ↑ | - | - | |||
| Tight junction protein | ||||||
| ZO-1 | - | - | - | ↓ | - | - |
| OCLN | - | - | - | - | - | - |
| CLDN1 | - | - | - | - | - | - |
| Cytokines | ||||||
| IL-8 | - | - | - | - | - | - |
| TNF-α | - | - | - | - | - | - |
| IL-1β | - | ↑ | - | - | - | - |
IBS-C, constipation type irritable bowel syndrome; IBS-D, diarrhea type irritable bowel syndrome; IBS-M, mixed type irritable bowel syndrome; TRPV1, transient receptor potential vanilloid-1; NGF, nerve growth factor; GDNF, glial derived neurotrophic factor; ZO-1, zonula occludens-1; OCLN, occludin; CLDN1, claudin-1; ↑, significantly increased; ↓, significantly decreased; -, not significant.