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Lung size reduction is apparent at the initiation of branching morphogenesis. (A,B) CDH1 whole-mount antibody staining outlined the epithelium of control and Shhcre;Mdm2 mutant lungs (A) at E13.5. B shows magnification of boxed region in A. (C,D) CDH1 whole-mount antibody staining of lungs at E11.5. (E,F) Nkx2-1 RNA in situ hybridization staining of lungs at E11.5. Staining data in this figure are representative from n=3 embryos of each genotype.
