Table 2.
Pharmacokinetic parameters of anti-MBG KoH bodies in serum following a single s.c. dose in C57BL/6 mice
| Parameter | Test article | |||
| KoH body A | KoH body B | KoH body C | Control mAb | |
| Cmax (μg/mL) | 12 ± 0.74 | 12 ± 1.3 | 14 ± 1.7 | 12 ± 0.57 |
| T1/2 (d) | 13 ± 0.53 | 13 ± 0.87 | 12 ± 1.7 | 11 ± 1.8 |
| AUClast (dμg/mL) | 174 ± 19 | 137 ± 38 | 205 ± 26 | 160 ± 20 |
| tmax (d) | 1.0 | 1.0 | 1.0 | 1.0 |
AUC, total area under the serum drug concentration–time curve; Cmax, maximum serum drug concentration during a dosing interval; T1/2, the time required to divide the serum concentration by 2 after reaching equilibrium; Tmax, time after drug administration when maximum serum concentration is reached.