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. 2019 Dec 23;117(1):513–521. doi: 10.1073/pnas.1821893117

Fig. 3.

Fig. 3.

Distinct consequences of loss of p107 and p130 on SCLC tumor progression. (A) Representative H&E-stained lung sections from Trp53/Rb1/Cas9 animals infected with Ad5-USEC harboring the indicated sgRNAs. Animals were analyzed 6 mo posttumor initiation. (Scale bars, 2 mm.) (B–D) Quantification of tumor burden (B), number of tumors (C), and mean tumor size (D) in Trp53/Rb1/Cas9 animals infected with Ad5-USEC harboring control sgRNA (n = 12), sgp130 (n = 12), or sgp107 (n = 10), 6 mo posttumor initiation. For (D), red indicates a data point that was identified as an outlier (Grubbs’ test, α < 0.001) and excluded from subsequent analyses. Data are presented as means with error bars denoting SD. ns: not significant, *P < 0.05, ***P < 0.001, ****P < 0.0001, 2-tailed Student’s t test. (E) Quantification of the number of animals presenting with mediastinal lymph node metastasis upon necropsy at 6 mo posttumor initiation. ns: not significant, *P < 0.05, ***P < 0.001, 2-sided Fisher’s exact test.