FIG 5.

The orientation of the V1 loop influences neutralization sensitivity to anti-V3 loop antibodies. Shown are homology models of 3H+109L, a precursor to PGT121 (magenta) (A and B), and 10-1074 bnAb (magenta) (C and D) interaction with relatively sensitive R5 (4102_61 [A and C] and 4102-2_17 [B and D]) (red) and less susceptible X4 (4102-3_6 [A and C] and 4102-3_5 [B and D]) (blue) Envs. The black spheres in each structure represent the predicted N332 sites. The blue spheres show the V3 loop insertions in the X4 strains compared to the R5 strains. The V1 loop is indicated with arrows.