TABLE 5.
Cellular genes in the type I interferon pathway downregulated with either CTCF or Rad21 KD
| Gene IDa | Mapped ID | Gene name | PANTHER protein class(es) (PANTHER ID[s]) |
|---|---|---|---|
| HUMAN|HGNC=11363|UniProtKB=P52630 | STAT2 | Signal transducer and activator of transcription 2 | Nucleic acid binding (PC00171), transcription factor (PC00218) |
| HUMAN|HGNC=5413|UniProtKB=Q01629 | IFITM2 | Interferon-induced transmembrane protein 2 | |
| HUMAN|HGNC=7533|UniProtKB=P20592 | MX2 | Interferon-induced GTP-binding protein Mx2 | Hydrolase (PC00121), microtubule family cytoskeletal protein (PC00085), small GTPase (PC00157) |
| HUMAN|HGNC=1119|UniProtKB=Q10589 | BST2 | Bone marrow stromal antigen 2 | |
| HUMAN|HGNC=30932|UniProtKB=Q6GPH4 | XAF | XIAP-associated factor 1 | |
| HUMAN|HGNC=6121|UniProtKB=O14896 | IRF6 | Interferon regulatory factor 6 | Nucleic acid binding (PC00171), transcription factor (PC00218) |
| HUMAN|HGNC=4963|UniProtKB=P30511 | HLA-F | HLA class I histocompatibility antigen, alpha chain F | Immunoglobulin receptor superfamily (PC00090), major histocompatibility complex antigen (PC00124) |
| HUMAN|HGNC=5411|UniProtKB=O14879 | IFIT3 | Interferon-induced protein with tetratricopeptide repeats 3 | |
| HUMAN|HGNC=5399|UniProtKB=P80217 | IFI35 | Interferon-induced 35-kDa protein | |
| HUMAN|HGNC=7532|UniProtKB=P20591 | MX1 | Interferon-induced GTP binding protein Mx1 | Hydrolase (PC00121), microtubule family cytoskeletal protein (PC00085), small GTPase (PC00157) |
| HUMAN|HGNC=8086|UniProtKB=P00973 | OAS1 | 2′,5′-Oligoadenylate synthase 1 | Defense/immunity protein, (PC00090), nucleic acid binding (PC00171), nucleotidyltransferase (PC00220) |
| HUMAN|HGNC=8090|UniProtKB=Q15646 | OASL | 2′,5′-Oligoadenylate synthase-like protein | Defense/immunity protein (PC00090), nucleic acid binding (PC00171), nucleotidyltransferase (PC00220) |
| HUMAN|HGNC=30908|UniProtKB=Q8WXG1 | RSAD2 | Radical S-adenosylmethionine domain-containing protein 2 | |
| HUMAN|HGNC=6130|UniProtKB=Q96AZ6 | ISG20 | Interferon-stimulated gene 20-kDa protein | Exoribonuclease (PC00171) |
| HUMAN|HGNC=5407|UniProtKB=P09914 | IFIT1 | Interferon-induced protein with tetratricopeptide repeats 1 | |
| HUMAN|HGNC=4054|UniProtKB=P09912 | IFI6 | Interferon alpha-inducible protein 6 | |
| HUMAN|HGNC=4053|UniProtKB=P05161 | ISG15 | Ubiquitin-like protein ISG15 | Ribosomal protein (PC00171) |
| HUMAN|HGNC=8088|UniProtKB=Q9Y6K5 | OAS3 | 2′,5′-Oligoadenylate synthase 3; OAS3; ortholog | Defense/immunity protein (PC00090), nucleic acid binding (PC00171), nucleotidyltransferase (PC00220) |
| HUMAN|HGNC=8087|UniProtKB=P29728 | OAS2 | 2′,5′-Oligoadenylate synthase 2 | Defense/immunity protein (PC00090), nucleic acid binding (PC00171), nucleotidyltransferase (PC00220) |
a
Species and HGNC and UniProt accession numbers for each gene are as listed.