FIG 8.
Replication and virulence of H7N9 viruses in BALB/c mice. (A) Virus titers in organs of mice. Data shown are the mean virus titers ± standard deviation (n = 3), except for the values labeled a and b, indicating that virus was detected only in the organs of 1 mouse and 2 mice, respectively. The dashed lines indicate the lower limit of virus detection. The virus titers in other virus-infected mice were compared with those in rCK/SD008-PB2/627K-infected mice, and statistical analysis was performed by using one-way ANOVA with GraphPad Prism 6 software. When one-way ANOVA was warranted, the post hoc analysis was performed using Dunnett’s test for multiple comparisons. *, P < 0.05; **, P < 0.01; ns, not significant. (B) Body weight changes in mice infected with the indicated viruses. (C) MLD50s values of mice infected with the indicated viruses.