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. 2019 Dec 16;117(1):308–316. doi: 10.1073/pnas.1915512116

Fig. 5.

Fig. 5.

Bioimaging of tumors in vivo using self-assembled biosynthesized GNC-PTEN complexes. (A) Dynamic biodistribution of normal saline, PTEN, GNC, and GNC-PTEN complexes in mice using fluorescent imaging at 0, 1, 6, 12, and 24 h (excitation wavelength: 420 nm, emission wavelength: 620 nm). (B) Quantitative analysis of the relative fluorescent light intensity. The fluorescent intensity of the control group was standardized to 1. (C) Twenty-four hours after injection, animals were killed and tumor (t, tumor) as well as major organs (l, liver; k, kidney; s, spleen; lu, lung; and h, heart) were collected for ex vivo imaging. (D) Fluorescent intensity of tumors in 4 groups. (E) Fluorescent intensity of individual organs in different treatment groups. The fluorescent intensity of the control group was standardized to 1. The fluorescent intensities of tumors are shown separately. (F) Inductively plasma mass spectrometer(ICP-MS) analysis of gold element in different organs of mice of the GNC-PTEN group after ex vivo imaging.