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. 2019 Dec 18;117(1):317–327. doi: 10.1073/pnas.1913690116

Fig. 6.

Fig. 6.

Proposed model of LukGH–CD11b-I interaction and pore formation. (I) Binding of LukGH to CD11b-I via the LukH protomer (Ia) results in recruitment of a second integrin molecule via the LukG protomer (Ib) or alternatively, recruitment of a second integrin molecule with bound LukGH dimer (Ic). (II) After recruitment of the second integrin, via the LukG protomer, further LukGH dimer molecules are bound either as soluble LukGH dimers (IIa) or LukGH dimers bound to integrins (IIb). In the alternative version, 2 LukGH dimers bound to the 2 integrins (IIc) recruit further LukGH dimers in the same way as in IIa and IIb. (III) Bending of the integrin and insertion of the octameric pore containing 2 to 4 bound integrins into the membrane.