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. 2019 Dec 23;117(1):552–562. doi: 10.1073/pnas.1906593116

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Copyright © 2020 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — Bioinformatically derived immunodominant peptides and homologous viral protein identification. (A) Predicted immunodominant peptides in topoisomerase I protein, (B) peptide sequences from microbial proteins homologous to topoisomerase I sequence, (C) 3D ribbon model of topoisomerase I with the identified immunodominant peptide in pink, (D) predicted immunodominant peptides in fibrillarin protein, (E) peptide sequences from microbial proteins homologous to fibrillarin sequence, (F) 3D ribbon model of fibrillarin protein with the identified immunodominant peptide in pink, (G) predicted immunodominant peptides in CENPA, (H) peptide sequences from microbial proteins homologous to CENPA sequence, and (I) 3D ribbon model of CENPA protein with the identified immunodominant peptide in pink. (These structures are based on PDB ID codes 1a35 for topoisomerase I, 2ipx for fibrillarin, and 3nqu for CENPA; $@$ in LD with DQA1*01:02/DQB1*06:09.)