Table 1.

Logistic regression and conditional analysis of HLA classical alleles in AA SSc

		Frequency (%)†	Unconditioned		Conditioned
	HLA allele	(SSc/Ctrls)	OR (95% CI)	P value	OR (95% CI)	P value
All SSc vs. controls	HLA-DRB1*08:04	24.3/9.3	3.2 (2.4-4.2)	3.26 × 10−16	3.2 (2.4-4.2)	3.26 × 10−16‡
SSc = 662; control = 946	HLA-DQB1*03:19	18.4/8.8	2.4 (1.8-3.2)	2.45 × 10−8
	HLA-DQB1*03:01	37/25.8	1.8 (1.4-2.2)	1.41 × 10−6
	HLA-DRB1*07:01	11.5/20.0	0.6 (0.4-0.7)	2.72 × 10−6
	HLA-DQA1*02:01	11.5/20.0	0.6 (0.4-0.7)	3.18 × 10−6
	HLA-DRB1*11:02	13.6/7.1	2.2 (1.6-3.0)	9.39 × 10−6	2.3 (1.6-3.2)	1.84 × 10−6
	HLA-DPA1*02:01	62.1/51.5	1.6 (1.3-1.9)	3.20 × 10−5
	HLA-DPB1*13:01	16.9/9.7	1.9 (1.4-2.6)	3.21 × 10−5
AFA+ SSc vs controls	HLA-DRB1*08:04	42.6/9.3	7.4 (4.9-11.3)	2.61 × 10−19	7.4 (4.9-11.3)	2.61 × 10−19‡
SSc = 129; control = 946	HLA-DQB1*06:09	20.9/6.6	3.8 (2.3-6.3)	1.37 × 10−6	4.1 (2.4-7.0)	2.04 × 10−6
	HLA-DQB1*03:01	45.0/25.8	2.5 (1.7-3.6)	9.16 × 10−6
	HLA-DQB1*03:19	22.5/8.8	3.0 (1.9-4.9)	2.53 × 10−5
	HLA-DRB1*13:02	29.5/13.8	2.6 (1.7-4.0)	3.70 × 10−5
ATA+ SSc vs. controls	HLA-DPB1*13:01	30.6/9.7	4.3 (2.9-6.3)	2.35 × 10−12	4.3 (2.9-6.3)	2.35 × 10−12‡
SSc = 183; control = 946	HLA-DQB1*02:01	7.7/25.1	0.3 (0.2-0.5)	1.10 × 10−8	0.3 (0.2-0.5)	2.17 × 10−7
	HLA-DRB1*03:01	3.3/14.9	0.2 (0.1-0.5)	4.92 × 10−7
	HLA-DQB1*03:01	43.7/25.8	2.3 (1.7-3.1)	2.64 × 10−6
	HLA-DPA1*02:01	69.9/51.5	2.3 (1.6-3.2)	2.73 × 10−6
	HLA-DRB1*08:04	21.3/9.3	2.8 (1.8-4.2)	8.13 × 10−6
	HLA-DQA1*05:01	51.4/39.1	1.6 (1.2-2.2)	2.90 × 10−3	2.1 (1.5-3.0)	2.21 × 10−5
ARA+ SSc vs. controls	None significant
SSc = 119; control = 946
ACA+ SSc vs. controls	None significant
SSc = 64; control = 946

Independent associations by conditional regression analyses are shown in bold.

^†Frequency of individuals with 1 or 2 alleles.

^‡Unconditioned; common AA haplotype: HLA-DRB1*08:04/DQA1*05:01/DQB1*03:01.