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. 2019 Dec 23;117(1):454–463. doi: 10.1073/pnas.1909145117

Fig. 6.

Fig. 6.

Schematic displays summarizing the regulation of AF-miRNAs and their target genes. (A) Circos plot summarizing the regulation of AF-miRNAs and their target genes. PPARG (black bar) is shown to up-regulate the here-validated miRNAs let-7g-5p, let-7c-5p, let-7a-5p, miR-338-3p, and miR-29c-3p. (B) Graphical model summarizing the transcriptional regulation of AF-miRNA–encoding genes by PPARG in HSCs. Reduced expression of PPARG upon activation of HSCs causes down-regulation of AF-miRNA expression. This permits elevated levels of profibrotic mRNAs, leading to the formation of a fibrotic ECM.