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(A) Principal shifts in secondary structure motifs at the transmembrane domain (TMD)/extra cellular domain (ECD) interface for 5-HT3A-5mM due to sustained binding events in bpCD and bpDE. Monomers C (pink), D (yellow), and E (orange) shown as secondary structure with initial structures colored as transparent white. Monomers A and B, and all M4 helices removed for clarity. Distances between the center of masses of the β1–β2 loops colored by monomers for 5-HT3A-Apo (B) and 5-HT3A-5mM (C).
