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. 2019 Dec 30;9(12):e025627. doi: 10.1136/bmjopen-2018-025627

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Effect of linaclotide treatment in patients with and without concomitant treatment for irritable bowel syndrome with constipation on (A) abdominal pain and (B) bloating. Visits 1 and 2 refer to baseline and week 4, respectively.