Table 2.
: Overview of data collection and study timings
| Study period | Pre-enrolment | T0 | T1 | T2 | T3 | T4 | T5 | T6 | T7 | T8 | T9 | T10 |
| Visits | ||||||||||||
| Screening (in-/exclusion criteria) | X | |||||||||||
| Written informed consent | X | |||||||||||
| Randomisation | X | |||||||||||
| Medical history | X | X | ||||||||||
| Neuroimaging (MRI/CT) | X | |||||||||||
| TMS-intervention (M1 iTBS/control iTBS) | X | X | X | X | X | X | X | X | ||||
| Physiotherapy | X | X | X | X | X | X | X | X | ||||
| Assessment of adverse events | X | X | X | X | X | X | X | X | X | X | X | |
| Relative grip strength | X | X | X | X | X | X | X | X | X | X | X | X |
| Documentation of medication | X | X | X | X | X | X | X | X | X | X | X | |
| Neurological examination | X | X | X | X | ||||||||
| Electrophysiological examination (RMT, MEPs) | X | X | X | |||||||||
| Upper limb motor function (ARAT, FM) | X | X | X | |||||||||
| Stroke severity (NIHSS) | X | X | X | |||||||||
| Disability (mRS) | X | X | X | |||||||||
| Quality of life (EQ-5D) | X | X | X | |||||||||
| Assessment of external rehabilitation time | X |
ARAT, Action Research Arm Test; EQ-5D, EuroQol 5D including the visual analogue scale; FM, Fugl-Meyer Motor Scale of the upper extremity;iTBS, intermittent theta burst stimulation; MEPs, Motor evoked potentials; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale;RMT, resting motor threshold.