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. 2020 Jan 9;10(1):e032620. doi: 10.1136/bmjopen-2019-032620

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Adverse effects of somatostatin treatment. Forest plots depicting the effect of somatostatin analogue treatment versus control on blood glucose (A), diarrhoea (B), abdominal pain (C), cholelithiasis and cholecystitis (D), alopecia (E) and discontinuation rates (F). Treatment with somatostatin resulted in increased risk of all assessed adverse effects. Horizontal lines represent the 95% CIs. The studies with risk ratio or standardised mean difference were indicated by coloured square. The diamond represented pooled risk ratio or standardised mean difference analysis with a 95% CI.