Table 1.
Genes Frequently Possessing Alterations In Lung Cancer
| Lung Tumour Types (WHO Classification22) | TP53 | EGRF | RB1 | KEAP1 | NOTCH1 | BRAF | MET | ERBB2 | RET | KRAS NF1 STK11 MAP2K1 NRAS HRAS ROS1 ALK | CDKN2A PTEN PIK3CA MLL2 HLA-A NFE2L2 | KIAA1211 COL22A1 RGS7 FPR1 CREBBP FMN2 | TMEM41B DEFB127 WDYHV1 TBPL1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Epithelial tumours | |||||||||||||
| Adenocarcinoma23–25 | X | X | X | X | X | X | X | X | |||||
| Squamous cell carcinoma24,26 | X | X | X | X | X | ||||||||
| Neuroendocrine tumours | |||||||||||||
| Small cell carcinoma27 | X | X | X | X | |||||||||
| Large cell neuroendocrine carcinoma28 | X | X | |||||||||||
| Carcinoid tumours29 | X | ||||||||||||
| Sarcomatoid carcinoma30 | X | X | X | X | X | X | |||||||