Table 4.
Univariate and Multivariate Analyses of Lymphocyte-Related Blood Parameters (LRBP) for DFS
| LRBP(n) | Higher n(%) | Lower n(%) | Univariate Analyses | Multivariate Analyses | ||
|---|---|---|---|---|---|---|
| HR(95% CI) | P-value | HR(95% CI) | P-value | |||
| Baseline LRBP | ||||||
| ALC(221) | 118(53.4%) | 103(46.6%) | 0.45(0.25–0.79) | 0.005 | 0.43(0.24–0.77) | 0.005 |
| NLR(221) | 81(36.7%) | 140(63.3%) | 2.12(1.18–3.82) | 0.007 | 2.40(1.35–4.27) | 0.003 |
| PLR(221) | 48(21.7%) | 173(78.3%) | 2.75(1.34–5.63) | <0.001 | 2.99(1.68–5.34) | <0.001 |
| Preoperative LRBP | ||||||
| ALC(221) | 106(48.0%) | 115(52.0%) | 0.49(0.28–0.86) | 0.017 | 0.42(0.23–0.76) | 0.004 |
| NLR(221) | 69(31.2%) | 152(68.8%) | 1.97(1.03–3.64) | 0.016 | 2.18(1.23–3.87) | 0.008 |
| PLR(221) | 159(71.9%) | 62(28.1%) | 1.85(0.97–3.52) | 0.032 | 2.01(1.12–3.60) | 0.020 |
| LRBP during RT | ||||||
| ALC (158) | 49(31.0%) | 109(69.0%) | 0.44(0.23–0.85) | 0.036 | 0.37(0.15–0.89) | 0.027 |
| NLR (158) | 30(19.0%) | 128(81.0%) | 1.54(0.72–3.29) | 0.250 | 1.55(0.72–3.33) | 0.265 |
| PLR (158) | 42(26.6%) | 116(73.4%) | 3.18(1.64–6.17) | <0.001 | 3.40(1.72–6.72) | <0.001 |
Abbreviations: DFS, disease-free survival; ALC, absolute lymphocyte counts; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; RT, radiation therapy; LRBP, lymphocyte-related blood parameters; HR, hazard ratio; CI, confidence interval.