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. 2020 Jan 8;14:61–71. doi: 10.2147/DDDT.S230358

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© 2020 Shi et al.

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Sappanone A (SA) regulated the phosphorylation of Nfr2. SA (20 mg/kg) was intraperitoneally administrated into rats 1 h prior to heart isolation, and then the rat hearts were isolated and underwent 30-min ischemia, followed by 120-min reperfusion. (A) Chelerythrine (CHE), a PKC inhibitor, was intraperitoneally administrated into rats at the dose of 1 mg/kg, 15 min prior to SA administration. (B) LY294002 (LY), a PI3K inhibitor was intraperitoneally administrated into rats at the dose of 0.3 mg/kg, 15 min prior to SA administration. The phosphorylation of Nfr2 (P-Nfr2) was detected by Western blotting. Data are expressed as the mean ± standard deviation, n=3. *P<0.05.