Table 3.
Univariate and Multivariate Analyses of Distant Metastasis-Free Survival for Patients with Cervical Squamous Carcinoma
| DMFS | DMFS | |||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |||
| LVI | 2.900 | 2.109 | 5.589 | <0.001 | 6.187 | 2.042 | 21.796 | 0.001 |
| LNM | 4.900 | 3.302 | 6.498 | <0.001 | 5.770 | 1.427 | 23.395 | 0.001 |
| TNM stage | 3.453 | 2.452 | 6.789 | <0.001 | – | – | – | – |
| Tumor budding | 6.923 | 5.469 | 7.481 | 0.005 | 2.782 | 1.372 | 5.891 | 0.007 |
| DR | 5.492 | 4.723 | 6.876 | 0.002 | 2.363 | 1.081 | 5.173 | 0.027 |
| CAF | 7.629 | 6.469 | 7.378 | 0.006 | – | – | – | – |
| VASH1 | 6.259 | 6.319 | 7.338 | 0.015 | – | – | – | – |
| VASH1/CD31 | 6.529 | 5.451 | 7.368 | 0.011 | – | – | – | – |
Notes: Statistical analysis was conducted by Log-rank tests and Cox proportional hazards model.
Abbreviations: LVI, lymph-vascular invasion; LNM, lymph node metastasis; TNM, tumor-node-metastasis; DR, desmoplastic reaction; CAF, cancer-associated fibroblasts; VASH1, vasohibin-1; CI, confidence interval; HR, hazard ratio; DMFS, distant metastasis-free survival.