Table 6.

A representation of exercise interventions done in Pompe disease. Number in parenthesis represents the article reference.

Exercise mode/N	Duration	Frequesncy	Intensity	Improved outcome
Cycling and Strength N = 5 (36)	20 weeks	3 days/week 10-15 min/session (week 1-3) 30 min/session (week 4-20)	Week 1-3: Cycling at level 1-2 Strength: ¼ squat, leg curl, knee raise, push-ups against a wall, back extensions, as well as sit ups, ¼ overhead press, elbow extensions and elbow curl 50% of 1RM, 2 sets x 10 reps Week 4-20: Cycling at level 2-4 50% of 1RM, 3 sets x 10 reps	Strength increased and 6MWT
Cycling, strength, and core stability N = 23 (37)	12 weeks	3 days/week	60% of VO2max 70% of 4RM One session consisted of: 5 minutes warm up 15 minutes cycling Shoulder extension, flexion and abduction, elbow flexion, knee extension and flexion, hip flexion, abduction and adduction: 3 sets x 15-20 reps 15 minutes cycling 3 x 30 seconds: Abdominal bridge, side bridge, back bridge	Climb 4 steps, muscle, strength in shoulder abductors and hip flexors, 6MWT, rise from supine to standing, workload, VO2max, ventilatory threshold, and core stability
High-protein and low-carbohydrate nutrition and exercise therapy Treadmill and upper body ergometer N = 34 (22 complied with nutrition and exercise therapy (38)	2y-10y	Daily 45 min/session on treadmill 10-15 min/session upper body ergometer	Not exceed RPE of 11–12	Slowing of deterioration in muscle function
SAVT N = 1 (39)	15 weeks	One cycle: 60 seconds vibration-on 60 seconds vibration-off	Vibration frequency 5 Hz, progressing to 20 Hz by week 11, and continuing at 20 Hz to week 15 Starting with two cycles initially, progressing to four cycles by week 11 and continuing with four cycles to week 15.	Improved strength and 6MWT