Table 2.

Summary of Reported Adverse Events During Treatment

	Single Administration				Multiple Administration
	Placebo (6)	Adrenomedullin			Placebo (6)	Adrenomedullin
Low (6)	Medium (6)	High (6)	High (6)
Any adverse event	1(16.7%)	0	3(50.0%)	2(33.3%)	1(16.7%)	3(50.0%)
Treatment-related adverse events	1(16.7%)	0	3(50.0%)	2(33.3%)	1(16.7%)	3(50.0%)
Severe adverse events	0	0	0	0	0	0
Serious adverse events	0	0	0	0	0	0
Deaths	0	0	0	0	0	0
Adverse events reported in >1 participant in any group
Nervous system disorders
Headache	1(16.7%)	0	1(16.7%)	1(16.7%)	0	3(50.0%)
Cardiac disorders
Palpitations	0	0	0	0	0	2(33.3%)
Wenckebach type atrioventricular block	0	0	2(33.3%)	1(16.7%)	0	0
Gastrointestinal disorders
Diarrhea	0	0	0	0	1(16.7%)	1(16.7%)