Table 4.

Hemodynamic Parameters of Participants Treated with the Multiple Doses Administration Test

		Adrenomedullin Infusion						Recovery
Pre	1 hr	2 hr	4 hr	6 hr	8 hr	9 hr	10 hr
SBP (mmHg)	Placebo	115.2 ± 7.1	112.9 ± 7.1*	112.1 ± 6.7**	114.1 ± 7.6	117.6 ± 7.8*	118.4 ± 8.2**	116.1 ± 7.1	117.2 ± 6.6
15 ng/kg/min	112.1 ± 6.2#	113.2 ± 5.5	110.4 ± 5.8	109.2 ± 7.6*, ##	112.3 ± 6.4##	113.6 ± 6.8##	110.5 ± 7.1##	111.7 ± 8.4##
DBP (mmHg)	Placebo	63.9 ± 4.7	60.1 ± 5.5**	61.1 ± 5.8**	61.4 ± 5.7**	60.5 ± 5.6**	61.6 ± 4.4*	62.1 ± 4.1*	64.7 ± 4.8
15 ng/kg/min	65.5 ± 5.4	57.0 ± 4.3**, ##	54.8 ± 4.2**, ##	54.8 ± 4.4**, ##	54.6 ± 4.2**, ##	54.9 ± 4.7**, ##	61.1 ± 5.0**	64.6 ± 5.3
PR (bpm)	Placebo	55.5 ± 6.7	58.7 ± 5.0**	56.7 ± 4.8	57.6 ± 4.8*	62.0 ± 4.7**	59.6 ± 5.5**	56.0 ± 5.2	55.8 ± 4.9
15 ng/kg/min	53.8 ± 5.4	61.6 ± 6.4**, #	59.7 ± 5.4**, #	62.5 ± 5.3**, ##	71.9 ± 5.9**, ##	70.7 ± 6.6**, ##	55.7 ± 5.7*	55.9 ± 5.7*

Notes: *P < 0.05, **P < 0.01, compared to pre values. ^#P < 0.05, ^##P < 0.01, compared to each point of placebo.

Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure; PR, pulse rate.