Table 5.
Adrenomedullin Pharmacokinetic Parameters
| Single Administration (12h) | Multiple Administration (8h) | ||||
|---|---|---|---|---|---|
| Low | Medium | High | Day 1 | Day 7 | |
| Cmax (pg/mL) | 10.0 ± 1.1 | 25.5 ± 3.7 | 50.4 ± 9.3 | 47.9 ± 10.9 | 64.2 ± 24.9 |
| Tmax (h) | 9.3 ± 4.7 | 10.7 ± 1.6 | 10.0 ± 2.2 | 7.2 ± 1.1 | 6.8 ± 1.1 |
| T1/2 (h) | 1.04 ± 0.92 | 0.30 ± 0.20 | 0.23 ± 0.15 | 0.45 ± 0.66 | 0.17 ± 0.07 |
| AUC0-24h (h*pg/mL) | 162.9 ± 21.2 | 295.4 ± 52.1 | 531.7 ± 91.5 | ― | 466.4 ± 121.8 |
| AUC0-10h (h*pg/mL) | ― | ― | ― | 272.3 ± 57.3 | 363.5 ± 114.3* |
Note: *P < 0.05, compared to day 1.
Abbreviations: Cmax, maximum measured plasma concentration; Tmax, time to maximum measured plasma concentration; T1/2, terminal plasma elimination half-life; AUC, cumulative area under the plasma concentration-time curve.