AUC 0–12 h	the area under the plasma concentration versus time curve calculated using the linear trapezoidal method
BCS	Biopharmaceutical Classification System
C max	the maximum plasma concentration of trans-resveratrol
CPP	critical process parameter
Cs	saturated solubility
CQA	critical quality attribute
CV	coefficient of variation
d90	the particle size at 90% cumulative volume percentage
DEGEE	diethylene glycol monoethyl ether
DLS	dynamic light scattering
HPC	hydroxypropyl cellulose
HPLC	high-performance liquid chromatography
HPMC	hydroxypropyl methyl cellulose
ICH	International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use
PRESS	predicted residual error sum of squares
PVP	polyvinylpyrrolidone
PVP VA	polyvinylpyrrolidone vinyl acetate
R 2	coefficient of determination
RA	risk assessment
RC	regenerated cellulose
SD	Sprague–Dawley
SLS	sodium lauryl sulfate
TEM	transmission electron microscope
T max	the time required to reach Cmax
USP	United States Pharmacopeia
QbD	quality by design
QTPP	quality target product profile