Table 2.

Optimisation results with different weighting factors in the objective function.

Weighting Factor, w1, for the Systemic Plasma Conc.	Weighting Factor, w2, for the Intracellular Conc.	kr37 (10−4 s−1)	kr42 (s−1)	Hyperthermia Duration (s)	Systemic Plasma Concentration (μg/mL)	Intracellular Concentration (ng/105 cells)
0	1	0.3	1.14	3600	0.26	0.56
0.25	0.75	0.3	1.1	3600	0.25	0.56
0.5	0.5	0.3	0.7	3600	0.24	0.55
0.75	0.25	0.3	0.13	3600	0.21	0.48
1	0	0.3	0.0114	3600	0.18	0.19