Table 2.

Gene mutations, locations, and mutation phenotypes of single nucleotide polymorphisms (SNPs) selected for this study.

Gene	Reference SNP	Gene Mutation *	Location and AA Change *	Mutation Phenotype
TNF	rs1800629	G > A	Promoter	Higher susceptibility to develop CD
TNFRSF1A	rs767455	C > T	Exon 4 (R > Q)	Poor response to anti-TNFα treatment in CD
TNFRSF1B	rs3397	C > T	Exon 10 (N/A)	Higher susceptibility to MAP infection in CD

* Gene mutation and location data were obtained from the National Center for Biotechnology Information (NCBI) [15]. (R: arginine; Q: glutamine; MAP: Mycobacterium avium subspecies paratuberculosis; CD: Crohn’s disease; MS: multiple sclerosis; N/A: unknown residue change).