Table 3.
Genotype frequencies of selected SNPs for RA patients and healthy controls.
| Genotype | RA Patients (n = 48) | Healthy Controls (n = 54) | p-value * | OR | 95% CI |
|---|---|---|---|---|---|
| TNFα:rs1800629 | |||||
| GG (Reference allele) | 29 (60%) | 44 (82%) | 0.03 | ||
| GA | 19 (40%) | 8 (15%) | 0.02 | 3.6 | 1.37–9.54 |
| AA | 0 (0%) | 2 (0%) | 0.23 | 0.2 | 0.01–3.36 |
| GA + AA | 19 (40%) | 10 (19%) | 0.04 | 2.9 | 1.17–7.07 |
| TNFRSF1A:rs767455 | |||||
| AA (Reference allele) | 22 (46%) | 29 (54%) | 0.42 | ||
| AG | 20 (42%) | 22 (41%) | 0.47 | 1.2 | 0.53–2.73 |
| GG | 6 (12%) | 3 (6%) | 0.17 | 2.6 | 0.59–11.7 |
| AG + GG | 26 (54%) | 25 (46%) | 0.31 | 1.4 | 0.63–2.99 |
| TNFRSF1B:rs3397 | |||||
| CC (Reference allele) | 18 (37%) | 38 (70%) | 0.02 | ||
| CT | 21 (44%) | 10 (19%) | 0.03 | 4.43 | 1.73–11.3 |
| TT | 9 (19%) | 6 (11%) | 0.29 | 3.17 | 0.98–10.3 |
| CT + TT | 30 (62%) | 16 (30%) | 0.03 | 4 | 1.73–9.05 |
Two-tailed Z test and odds ratio analysis were used to compare the presence of SNPs in CD patients vs. healthy controls. * p-value of < 0.05 was considered as the significance threshold. (RA: rheumatoid arthritis; SNP: single nucleotide polymorphism; OR: odds ratio (crude); CI: confidence interval).