Table 3.
Top 30 upregulated genes (AAA gene list, part 1) in AAA versus AOD, including fold change (FC), p-value, location in the cell (location), type of molecule, and presence in the vascular gene set.
| Gene Symbol | Entrez Gene Name | Fold Change | p-Value | Location | Type(s) | Vascular Gene Set |
|---|---|---|---|---|---|---|
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 32.269 | 1.12 × 10−4 | Extracellular Space | Cytokine | YES |
| COL11A1 | collagen, type XI, alpha 1 | 27.046 | 5.29 × 10−5 | Extracellular Space | Other | YES |
| SAA2 | serum amyloid A2 | 24.96 | 3.95 × 10−7 | Extracellular Space | Other | NO |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | 21.454 | 3.01 × 10−4 | Extracellular Space | Other | YES |
| FDCSP | follicular dendritic cell secreted protein | 21.38 | 1.01 × 10−4 | Extracellular Space | Other | NO |
| POU2AF1 | POU class 2 associating factor 1 | 18.842 | 4.79 × 10−4 | Nucleus | transcription regulator | NO |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 18.414 | 2.61 × 10−4 | Plasma Membrane | Other | YES |
| MZB1 | marginal zone B and B1 cell-specific protein | 17.072 | 1.26 × 10−3 | Extracellular Space | Other | NO |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 15.716 | 5.37 × 10−7 | Plasma Membrane | Transporter | YES |
| LEP | leptin | 14.288 | 1.94 × 10−6 | Extracellular Space | growth factor | YES |
| MARCO | macrophage receptor with collagenous structure | 13.563 | 4.12 × 10−4 | Plasma Membrane | transmembrane receptor | YES |
| LPL | lipoprotein lipase | 12.984 | 3.51 × 10−5 | Cytoplasm | Enzyme | YES |
| IL1RN | interleukin 1 receptor antagonist | 12.873 | 1.16 × 10−3 | Extracellular Space | Cytokine | YES |
| IGLL5 | immunoglobulin lambda-like polypeptide 1 | 12.848 | 9.73 × 10−4 | Plasma Membrane | Other | NO |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 12.123 | 1.13 × 10−3 | Plasma Membrane | transmembrane receptor | NO |
| KIAA1199 | KIAA1199 | 12.122 | 1.60 × 10−3 | Cytoplasm | Other | YES |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 11.851 | 4.33 × 10−4 | Plasma Membrane | transmembrane receptor | YES |
| P2RX5 | purinergic receptor P2X, ligand-gated ion channel, 5 | 11.706 | 8.53 × 10-5 | Plasma Membrane | ion channel | NO |
| HMOX1 | heme oxygenase (decycling) 1 | 10.932 | 5.47 × 10−5 | Cytoplasm | Enzyme | YES |
| IGLJ3 | immunoglobulin lambda joining 3 | 10.776 | 7.29 × 10−3 | Other | Other | NO |
| IGH | immunoglobulin heavy locus | 10.257 | 4.24 × 10−4 | Other | Other | NO |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 10.238 | 1.31 × 10−5 | Nucleus | Enzyme | NO |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | 10.164 | 1.51 × 10−4 | Extracellular Space | Cytokine | YES |
| CD79A | CD79a molecule, immunoglobulin-associated alpha | 10.064 | 1.97 × 10−4 | Plasma Membrane | transmembrane receptor | NO |
| FNDC1 | fibronectin type III domain containing 1 | 10.028 | 2.80 × 10−4 | Plasma Membrane | Other | YES |
| TIMD4 | T-cell immunoglobulin and mucin domain containing 4 | 9.859 | 2.59 × 10−3 | Plasma Membrane | Other | NO |
| PIM2 | pim-2 oncogene | 9.838 | 2.35 × 10−4 | Other | Kinase | YES |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 9.659 | 2.76 × 10−4 | Extracellular Space | Cytokine | YES |
| FCRL5 | Fc receptor-like 5 | 9.596 | 2.49 × 10−3 | Other | Other | NO |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 9.526 | 3.06 × 10−6 | Extracellular Space | Cytokine | YES |