Table 4.
Ingenuity® Pathway Analysis of significantly changed genes within each brain region and time point.
| Top Canonical Pathways | Top Upstream Regulators | Top Molecular and Cellular Functions | |
|---|---|---|---|
| STR 2 h post-METH, FDR <0.05 | NRF2-mediated oxidative stress response | Lipopolysaccharide | Cell death and survival |
| Aryl hydrocarbon receptor signaling | PDGF BB | Cellular movement | |
| Unfolded protein response | Beta-estradiol | Cellular development | |
| Aldosterone signaling in epithelial cells | HSF1 | Cellular growth and proliferation | |
| LXR/RXR activation | TNF | Cell morphology | |
| PFC 2 h post-METH, FDR <0.05 | Aldosterone signaling in epithelial cells | Lipopolysaccharide | Cellular movement |
| Unfolded protein response | IFNG | Cell death and survival | |
| Atherosclerosis signaling | TGFB1 | Protein synthesis | |
| Granulocyte adhesion and diapedesis | IL1B | Cellular function and maintenance | |
| IL-10 signaling | PDGF BB | Cellular development | |
| STR 3 day post-METH, FDR <0.05 | EIF2 signaling | TCR | RNA post-transcriptional modification |
| Regulation of eIF4 and p70S6K signaling | ERBB2 | Protein synthesis | |
| mTOR signaling | DOT1L | Cell death and survival | |
| Type I diabetes mellitus signaling | EBI3 | Gene expression | |
| T helper cell differentiation | DRAP1 | DNA replication, recombination, and repair | |
| PFC 3 day post-METH, FDR <0.05 | N/A | N/A | N/A |