Table 5.
Ingenuity® Pathway Analysis of significantly changed genes in STR at both 2 h and 3 days post-METH.
| Top Canonical Pathways | Top Upstream Regulators | Top Molecular and Cellular Functions | |
|---|---|---|---|
| Upregulated at both 2 h and 3 day post-METH | EIF2 signaling | TCR | RNA post-transcriptional modification |
| Regulation of eIF4 and p70S6K signaling | DOT1L | Protein synthesis | |
| mTOR signaling | HSP90B1 | Gene expression | |
| Hepatic fibrosis/hepatic stellate cell activation | miR-542-3p (miRNAs w/seed GUGACAG) | Cell morphology | |
| Complement system | ELAVL1 | Cell-to-cell signaling and interaction | |
| Downregulated at both 2 h and 3 day post-METH | Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | BHLHA15 | Cellular assembly and organization |
| NAD biosynthesis II (from tryptophan) | SOX11 | DNA replication, recombination, and repair | |
| Leukotriene biosynthesis | ERBB2 | Cell cycle | |
| -Glutamyl cycle | NAMPT | Cellular growth and proliferation | |
| Mismatch repair in eukaryotes | CERS6 | Cell morphology | |
| Upregulated at 2 h and downregulated at 3 day | -Linolenate biosynthesis II (animals) | FAM103A1 | Cellular assembly and organization |
| Myc mediated apoptosis signaling | IKBKE | DNA replication, Recombination and repair | |
| Glycine biosynthesis I | PIM1 | Cell morphology | |
| Pancreatic adenocarcinoma signaling | RELB | Cell death and survival | |
| S-adenosyl-L-methionine biosynthesis | NFKB2 | Cell cycle | |
| Downregulated at 2 h and upregulated at 3 day | NAD salvage pathway II | NDRG1 | Lipid metabolism |
| IL-22 signaling | COL18A1 | Small molecule biochemistry | |
| Natural killer cell signaling | CDK4 | Cell morphology | |
| PI3K/AKT signaling | PDLIM2 | Cellular function and maintenance | |
| Interferon signaling | CLDN7 | Cell death and survival |