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. 2019 Dec 1;7(12):636. doi: 10.3390/microorganisms7120636

Figure 1.

Figure 1

Bacterial abundance and diversity in samples of Active and Passive recurrent aphthous stomatitis (RAS) patients and healthy controls from lower labial mucosa (LL). (A) Alpha diversity expressed as the number of operational taxonomic units (OTUs), Chao1 index, Shannon index, and Evenness at the site of ulceration (Act_A), at the site around ulceration (Act_AS), at a contralateral unaffected site of the oral cavity of RAS patients (Act_CHS), in RAS patients without manifested ulcer (Pas) and in healthy controls (Ctrl). (B) Beta diversity of the LL site is presented in the form of PCoA plot. (C) Taxonomic profile of the bacterial community at the species level shows the most abundant bacterial species in RAS patients at the site of ulceration (Act_A), in RAS patients without manifested ulcer (Pas), and in healthy controls (Ctrl). (D) LEfSe (LDA Effect Size) algorithm revealed increased levels of some genera in patients with RAS. Significant differences are denoted by * p < 0.05 and ** p < 0.01.