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. 2019 Nov 21;7(12):593. doi: 10.3390/microorganisms7120593

Figure 2.

Figure 2

Schematic representation of possible MALDI-TOF MS spectra patterns for direct determination and identification of antimicrobial resistance. (A) Sensitive strain. (B) Detection of antimicrobial resistance by the detection of metabolites related to the degradation of the antibiotic. (C) Detection of antimicrobial resistance by the detection of a peak shift, which could be related to a mutation in the biomarker gene that confers antimicrobial resistance (AMR). (D) Detection of antimicrobial resistance by the detection of unique biomarkers, which could be related to the production of a specific molecule (e.g., enzymes, porins). (*) Peak differences in comparison with the sensitive strain spectra (A).