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. 2019 Dec 1;11(12):640. doi: 10.3390/pharmaceutics11120640

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Histology of (A) (group 1) ventral lobe of intact rats, H&E, ×40; (B) (group 2) testosterone-induced BPH (benign prostatic hyperplasia) (irregular acinar shape with villous projections of different sizes into the lumen), ×40; (C) (group 3) 14 days of co-administration of testosterone and the plain formula (irregular acinar shape with villous projections of different sizes into the lumen), ×40; (D) (group 4) 14 days of co-administration of testosterone and optimized TDL-PSO SNEDDS (normalized ventral lobe structure), H&E, ×60; (E) (group 5) 14 days of co-administration of testosterone with TDL 2 mg/kg (glands are partially atrophic, with dilated, angular, profiles and adenomatous hyperplasia), H&E, ×60; and (F) (group 6) 14 days of co-administration of testosterone and PSO 100 mg/kg (glands are partially atrophic, with dilated, angular, profiles and adenomatous hyperplasia), H&E, ×60.