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. 2019 Dec 4;11(12):653. doi: 10.3390/pharmaceutics11120653

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Initial low-volume, high-throughput screening of liposomes formulated using different solvents during microfluidic production. Liposomes were prepared using a low volume, high throughput screening system (Spark^TM). Different water miscible organic solvents (methanol, ethanol or IPA) were used in combination with the aqueous phase. A flow rate ratio of 3:1 aqueous:organic phase was used with 4 mg/mL total lipid concentration in the organic phase. Various liposome formulations were tested: (A) soyPC:Chol 3:1 w/w, (B) POPC:Chol 3:1 w/w, (C) DMPC:Chol 2:1 w/w, (D) DSPC:Chol 2:1 w/w, (E) HSPC:Chol 2:1 w/w, (F) DSPC:Chol:DSPE-PEG2k 2:1:1 w/w. Columns represent particle size and open circles represent PDI. Results represent mean ± SD from three independent batches.