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Cumulative permeation of NIA from binary and ternary solvent systems in porcine skin following the application of 5 μL/cm2 of formulations. (A) shows the permeation profiles of PG:T-BA(●), PG:OA(■), PG:TC(◆), PG:DMI(▲), PG:LA(▄), PG:TC:DMI (50:25:25, ●); (B) shows the permeation profiles of TC:T-BA(●), TC:DMI(■), TC:PG:DMI (50:25:25, ■) and TC:CCT:DMI (50:25:25, ◆). Each data point represents the mean ± SD, n = 4. * p < 0.05.
