Table 4.
Changes in intestinal microbiota associated with clinical studies on primary sclerosing cholangitis.
| Phylum | Class | Order | Family | Genus |
|---|---|---|---|---|
| Firmicutes | Bacilli | Lactobacilales | Lactobacillaceae | Lactobacillus ↑ [241] |
| Streptococcaceae | Streptococcus ↑ [249] ↑ # [249] (S. infantis ↑ [249] ↑ # [249] S. alactolyticus ↑ [252] ↑ # [252] S. equi ↑ [249] ↑] # [249], S. parasanguinis [252] ↑ # [252]) |
|||
| Enterococcaceae | Enterococcus ↑ [241,249,252] (E. faecium ↑ [252], E.sp.NBRC107345 ↑ [252]) |
|||
| Clostridia | Clostridiales | Clostridiaceae | Clostridium ↑ [249] | |
| Clostridiales II ↓ [239] ↓ # [239] | ||||
| Ruminococcaceae | Ruminococcus ↑ # [246,252] (R. gnavus ↓ [249], R. obeum ↑ § [245]) |
|||
| Faecalibacterium ↑ # [251] (F. prausnitzii ↓ [249]) |
||||
| Dorea ↓ # [246] | ||||
| Roseburia ↑ # [251] ↓ # [246] ↓ [§267] | ||||
| Blautia ↑ § [245] ↓ # [246] (B. obeum ↑ § [245] ↓ [252], B. faecis ↑ § [245]) |
||||
| Coprococcus ↓ [240,249] (C. catus ↓ [249]) |
||||
| Lachnospiraceae ↑ § [248] | Anaerostipes (A. hardus ↓ [252]) |
|||
| Lachnospira ↓ # [246] | ||||
| Negativicutes ↑ [187] | Selenomonadales | Veillonellaceae ↑ [38,187,204] | Veilonella ↑ [240,249,251] ↑ # [240,249] ↓ # [246] |
|
| Acidominococcaceae | (V. dispar ↑ [249], ↑ # [249] V. paruvula ↑249], ↑ # [249] V.sp.3_1_44 ↑ [252]) Megasphaera ↑ [240] ↑ § [249] Phascolarctobacterium ↓ [240] |
|||
| Actinobacteria | Actinobacteria | Actinomycetales | Micrococcaceae ↑ [249] | Rothia ↑ [249] ↑ # [249] (R. mucilaginosa ↑ [249]) |
| Coriobacteriales | Coriobacteriaceae | Adlercreutzia ↓ [249] (A. equolifaciens ↓ [249] ↓ # [249]) |
||
| Fusobacteria | Fusobacteriia | Fusobacteriales | Fusobacteriaceae | Fusobacterium ↑ [241] ↑ # [246] |
| Bacteroidetes | Bacteroidia | Bacteroidales | Bacteroidaceae | Bacteroides ↓ § [249] |
| Prevotellaceae | Prevotella ↓ § [249] (P. corpi ↓ [249], ↓ # [249]) |
|||
| Porphydomonadaceae | Parabacteroides ↓ # [252] (P. distasonis ↓ [252]) |
|||
| Barnesiellaceae ↑ [245] | ||||
| Proteobacteria | γ-proteobacteria | Enterobacteriales | Enterobacteriaceae | Escherichia ↑ § [249] |
| Pasteurellales | Pasteurellaceae | Haemophilus ↑ [249] | ||
| Aeromonadales | Succinivibrionaceae | Succinivibrio ↓ [240] | ||
| Desulfovibrionales | Desulfovibrionaceae | Desulfovibrio ↓ [240] |
# Bajer L et al. Resuls in patients with PSC (both with and without IBD.); # Iwasawa K, et al. Reslts in patients with PSC. # Rossen NG, et al. Reslts in patients with PSC compared with those with IBD and control. § Quraishi MN, et al. Results in patients with PSC compared with IBD and control. # Kummen M, et al. Results in patients with PSC compared with those with IBD and control.