Table 4.
Summary of the five studies with reported continuous neurodevelopmental outcomes.
| Study | Assessment Tool | Sepsis Group | Non-sepsis Group | Attrition Rate | Comments |
|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | ||||
| Shah [55] | MDI (BSID-II) | 79.7 (21.2) | 86.5 (18.7) | 6% | N/A |
| PDI (BSID-II) | 84.2 (21.4) | 89.9 (14.5) | |||
| Van der Ree [64] | Movement ABC Total (M-ABC2)—raw score | 13 (10) | 8 (6) | N/A | N/A |
| Total intelligence (WISC-II)—IQ | 89 (13) | 98 (8) | |||
| Total behavioural problems (CBCL)—t-scores | 53 (12) | 56 (9) | |||
| Hentges [58] | MDI (BSID-II) | 85.9 (10.8) | 86.1 (11.59) | 22% | N/A |
| PDI (BSID-II) | 89.8 (13.3) | 91.7 (14.02) | |||
| Young [61] # | At 2 years: BSID-III | NS | NS | N/A | Sepsis was not significant with 2-year or 4-year cognitive measures, but significant with 4-year behavioural measures. |
| At 4 years: WPPI-III, CLEF-2, Beery–Buktenica Test of Visual Motor Integration, the Behaviour Assessment System for Children Parent Rating Scales, Behavioural Rating Inventory of Executive Functioning – Preschool | |||||
| Zonnenberg [62] | MDI (BSID-II) | 100 (9.0) | 98 (13.9) | 23% | N/A |
| PDI (BSID-II) | 100 (9.4) | 99 (12.3) | |||
| Lexiquotient (Lexilijst) | 91 (16.1) | 88 (18.2) | |||
| Total behavioural score (CBCL) | 26 (14.9) | 30 (21.2) | |||
| Total internalising score (CBCL) | 5 (4.3) | 8 (7.9) | |||
| Total externalising score (CBCL) | 12 (7.5) | 12 (7.6) | |||
| Median: 22% |
#: Studies did not report group mean and SD for sepsis and non-sepsis group. NS—not specified.