The microbial biomass, the metabolites concentration, and the gene expression of Schizosaccharomyces pombe C-11 in the +AA 10 g/L and none group samples in the mono-culture fermentation process. (a) The microbial biomass; (b,c) the concentration of acetic acid and mevalonic acid in the +AA 10 g/L and none group samples during the fermentation process; (d) the relative expression ratios of genes ADH5, ACH1, ACS2, HXT1, ACCAT1, HMGCS1, and HMGCR1 in +AA 10 g/L group as compared to the none group at 12 h and 24 h. In the +AA 10 g/L group samples, the mono-culture process using Schi. pombe C-11 under initial concentration of 10 g/L acetic acid; and in the none group samples, the mono-culture process using Schi. pombe C-11 without initial concentration of 10 g/L acetic acid. The length in each square frame represents relative gene expression ratio based on real-time quantitative PCR at 12 h and 24 h, respectively. Data are expressed as mean ± SD from biological triplicates. Error bars indicate standard deviation from three independent experiments and asterisks represent significant differences between the two groups (* p < 0.05, ** p < 0.01, *** p < 0.001, Mann–Whitney U test).