Table 2.
Biological Pathways Disrupted in Brain Tissue from Alcohol-Dependent Patients. Pathways most commonly up-regulated (left) or down-regulated (right) in brain tissue from alcohol-dependent patients versus control. The full results are in Table S1.
| Up-Regulated Pathways | Down-Regulated Pathways | ||
|---|---|---|---|
| KEGG Pathway | Number of Datasets (out of 17) | KEGG Pathway | Number of Datasets (out of 17) |
| Complement_and_coagulation_cascades | 8 | Oxidative_phosphorylation | 6 |
| Focal_adhesion | 8 | Parkinsons_disease | 4 |
| Mapk_signaling_pathway | 8 | Proteasome | 4 |
| Systemic_lupus_erythematosus | 8 | Alzheimers_disease | 3 |
| Cytokine_cytokine_receptor_interaction | 7 | Cardiac_muscle_contraction | 2 |
| Ecm_receptor_interaction | 7 | Dna_replication | 2 |
| Cell_adhesion_molecules_cams | 6 | Fructose_and_mannose_metabolism | 2 |
| Leishmania_infection | 6 | Glycolysis_gluconeogenesis | 2 |
| Regulation_of_actin_cytoskeleton | 6 | Huntingtons_disease | 2 |
| Ribosome | 6 | Mismatch_repair | 2 |
| Leukocyte_transendothelial_migration | 5 | Propanoate_metabolism | 2 |
| Natural_killer_cell_mediated_cytotoxicity | 5 | Vibrio_cholerae_infection | 2 |
| Pathways_in_cancer | 5 | ||