Table 3.
Biological Pathways Disrupted in Brain Tissue from Alcohol-Dependent Patients. Pathways most commonly up-regulated (top) and down-regulated (bottom) in alcohol-dependent versus control brain tissue. The brain region of the gene expression datasets is shown in the first column. The number in parentheses indicates the number of datasets that profiled gene expression in that brain region. The numbers in the table indicate the number of datasets from that brain region in which the pathway was disrupted. For example, focal adhesion was upregulated in three out of three basolateral amygdala datasets and two out of five prefrontal cortex datasets. BLA: basolateral amygdala, CNA: central nucleus of the amygdala, PFC: prefrontal cortex, NAC: nucleus accumbens, VTA: ventral tegmental area, HPC: hippocampus.
| Brain Region | Focal Adhesion | Complement and Coagulation Cascades | Mapk Signaling Pathway | Systemic Lupus Erythematosus |
| BLA (3) | 3 | 2 | 1 | 2 |
| CNA (3) | 1 | 2 | 2 | 1 |
| PFC (5) | 2 | 3 | 3 | 3 |
| NAC (3) | 1 | 1 | ||
| VTA (1) | 1 | |||
| HPC (2) | 1 | 1 | 2 | |
| Brain Region | Oxidative Phosphorylation | Parkinsons Disease | Proteasome | Alzheimers Disease |
| BLA (3) | 1 | |||
| CNA (3) | 1 | 1 | 1 | |
| PFC (5) | 2 | 2 | 1 | |
| NAC (3) | 2 | 1 | 1 | 1 |
| VTA (1) | ||||
| HPC (2) | 1 | 1 | 1 |