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. 2019 Dec 3;11(12):646. doi: 10.3390/pharmaceutics11120646

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A–C): Calcein release of different liposomal formulations during 3 h of incubation at 37 °C in (A) phosphate buffered saline (PBS) at pH = 7.4, (B) simulated gastric fluid (SGF) at = pH 1.0, and (C) simulated intestinal fluid (SIF) at pH = 8.0. (D–F): Volume-weighted particle size distribution of vesicle suspensions after 4 h of incubation at 37 °C in (D) PBS at pH = 7.4, (E) SGF at pH = 1.0, and (F) SIF at pH = 8.0. As liposomal formulations, pure DOPC (black squares, dashed line), pure phospha-tidylcholines from soy beans (soyPC) (black diamonds, dotted line), PC-C32(1,32C6)-PC/DOPC (1/4; blue data), PC-C32(1,32C9)-PC/DOPC (1/4; orange data), and PC-C32(1,32C9)-PC/soyPC (1/4; green data) were used.