Michielsen 2013.

Methods	Study design: prospective, randomised controlled clinical trial Number of study centres: 1 probably Study dates: not reported Participants randomly assigned: unclear
Participants	Inclusion criteria: people with intermediate risk of non‐muscle invasive urothelial carcinoma of the bladder Exclusion criteria: not reported
Interventions	Group A: MMC 40 mg in 50 mL 0.9% saline Group B: BCG full dose Procedure: treatments weekly for 6 weeks, each group had a specific maintenance programme.
Outcomes	Disease‐specific quality of life, measured with EORTC QLQ BLS24
Funding sources	No information reported.
Declarations of interest	No information reported.
Notes	Congress abstract available only.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Comment: no information reported to allow a judgement.
Allocation concealment (selection bias)	Unclear risk	Comment: no information reported to allow a judgement.
Blinding of participants and personnel (performance bias) all outcomes	Unclear risk	Comment: no information reported to allow a judgement.
Blinding of outcome assessment (detection bias) overall survival	Unclear risk	Comment: no information reported to allow a judgement.
Blinding of outcome assessment (detection bias) recurrence and progression free survival	Unclear risk	Comment: no information reported to allow a judgement.
Blinding of outcome assessment (detection bias) serious and non‐serious adverse effects	Unclear risk	Comment: no information reported to allow a judgement.
Blinding of outcome assessment (detection bias) quality of life	Unclear risk	Comment: no information reported to allow a judgement.
Incomplete outcome data (attrition bias) Survival outcomes	Unclear risk	Comment: no information reported to allow a judgement.
Incomplete outcome data (attrition bias) Adverse effect outcomes	Unclear risk	Comment: no information reported to allow a judgement.
Incomplete outcome data (attrition bias) Quality of life outcomes	Unclear risk	Comment: no information reported to allow a judgement.
Selective reporting (reporting bias)	Unclear risk	Comment: no study protocol available.
Other bias	Unclear risk	Comment: no information reported to allow a judgement.