Figure 8.
6-bromotryptamine A reduces Aβ1–42 oligomer formation in a dose-dependent manner. The Aβ1–42 monomer was co-incubated with 6-bromotryptamine A at the indicated doses for 2 days. The solution was centrifuged, and the supernatants were then analyzed. (A) Dot blot analysis was performed with A11 (an anti-oligomer antibody) and 6E10 (an anti-Aβ antibody). (B) The bands from three independent experiments were quantified via densitometry and are represented graphically. Data are presented as the mean ± standard error of the mean. #P<0.05 and ##P<0.01, vs. control group (analysis of variance and Tukey's test).