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. 2019 Dec 1;11(12):639. doi: 10.3390/pharmaceutics11120639

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Impact of stratum corneum (SC) solubility and apparent diffusivity D* on the maximum flux J_max for curcumin. (A). J_max versus S_sc for control vehicles only excluding 60% ethanol; (B). J_max versus S_sc; (C). J_max versus D*. Black symbols—for control vehicles; purple symbols—60% EtOH/water; red symbols—nanoemulsion formulations. It is evident from Figure 7C that the J_max is better related to D*.