Table 2.

Effect of different component composition in mg/mL on NIO particle size (p.s.), ζ-potential (ζ.pot.), and polydispersion index (PDI).

Batch	Span 60	Span 40	CHL	CHE	SOL	HPβCD	p.s. (nm ± s.d.)	PDI ± s.d.	ζ.pot. (mV ± s.d.)
0	8.00		5.73		5.33		135.37 ± 2.22	0.21 ± 0.01	−15.57 ± 0.35
1	5.73		9.53		3.81		418.47 ± 6.29	0.31 ± 0.04	−22.40 ± 1.32
2	11.43		4.75		2.86		362.97 ± 2.22	0.32 ± 0.04	−27.30 ± 2.38
3	13.34		2.86		2.86		301.70 ± 4.11	0.25 ± 0.02	−21.30 ± 1.78
4		8.00					227.07 ± 3.63	0.29 ± 0.01	−18.77 ± 0.78
5				5.73			214.37 ± 6.28	0.32 ± 0.04	−21.10 ± 1.15
6		8.00		5.73			189.93 ± 3.76	0.26 ± 0.01	−20.43 ± 0.64
7	8.00		5.73		5.33	4.88	159.17 ± 0.55	0.19 ± 0.01	−19.40 ± 2.31