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. 2019 Nov 25;19(2):1322–1330. doi: 10.3892/ol.2019.11148

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Copyright: © Yin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — IDH1-R132H epigenetically decreases TIGAR expression. (A) TIGAR expression was reduced in IDH1-R132H-expressing U87MG cells, but not in U87MG-GSCs. *P<0.05 vs. empty vector-transfected group. (B) The effects of IDH1-R132H inhibitor AGI-5198 on the expression of TIGAR and H3K9me3. *P<0.05 vs. control group, ^#P<0.05 vs. pCMV–IDH1-R132H-transfected group. (C) Chromatin immunoprecipitation assay demonstrated the interaction between H3K9me3 and the TIGAR promoter. *P<0.05 vs. empty vector-transfected group. IDH1, isocitrate dehydrogenase 1; WT, wild-type; TCGA, The Cancer Genome Atlas; TIGAR, TP53-induced glycolysis and apoptosis regulator; GSC, glioma stem-like cells; IgG, immunoglobulin G; H3K9me3, histone H3 lysine 9 trimethylation.