Table I.
Clinical and histopathological characteristics of patients with OSCC and healthy controls.
| Patients with OSCC | Healthy controls | P-value | |||||
|---|---|---|---|---|---|---|---|
| Patient characteristic | n=40 | % | n=30 | % | |||
| Mean age (years) | 57±7 | 56±5 | 0.130 | ||||
| Risks factors | |||||||
| Tobacco consumption | 38 | 95.0 | 4 | 13.3 | <0.001 | ||
| Alcohol consumption | 32 | 80.0 | 0 | 0 | <0.001 | ||
| Location of tumor | |||||||
| Base of tongue | 18 | 45.0 | − | − | − | ||
| Tonsil | 15 | 37.5 | − | − | − | ||
| Tongue | 5 | 12.5 | − | − | − | ||
| Lip | 2 | 5.0 | − | − | − | ||
| Tumor differentiation grading | |||||||
| G1 | 22 | 55.0 | − | − | − | ||
| G2 | 8 | 20.0 | − | − | − | ||
| G3 | 10 | 25.0 | − | − | − | ||
| Tumor size-depth of invasion | |||||||
| T-DOI I (T ≤4 cm; DOI ≤10 mm) | 15 | 37.5 | − | − | − | ||
| T-DOI II (T >4 cm; DOI >10 mm) | 25 | 62.5 | − | − | − | ||
| Lymph node involvement | |||||||
| Negative (N0) | 17 | 42.5 | − | − | − | ||
| Positive (N1 + N2 + N3) | 23 | 57.5 | − | − | − | ||
| Melatonin (pg/ml)a | 18.2 (11.0–39.2) | 47.6 (37.7–66.4) | <0.001 | ||||
a
Data are expressed as the median values and interquartile ranges (25–75%). OSCC, oral squamous cell carcinoma; T, tumor size; DOI, depth of invasion.