2. GRADE assessments: glucocorticoid versus placebo.

Population	Outcome	Number of studies	Number of participants	GRADE domains				Strength of evidence	Intervention favoured
				Risk of bias	Consistency	Directness	Precision
GLUCOCORTICOID versus PLACEBO
Inpatients	Length of stay	8	633	Medium	Consistent	Direct	Precise	High	No difference
	Clinical score : 3 to 6 hours	1	26	Medium	Unknown	Direct	Imprecise	Low	Glucocorticoid
	Clinical score : 6 to 12 hours	3	175	Medium	Consistent	Direct	Imprecise	Moderate	Glucocorticoid
	Clinical score : 12 to 24 hours	3	230	Medium	Consistent	Direct	Imprecise	Moderate	No difference (glucocorticoid favoured)
	Clinical score : 24 to 72 hours	4	113	Medium	Inconsistent	Direct	Imprecise	Low	No difference (glucocorticoid favoured; very close to significant)
Outpatients	Admissions day 1	8	1762	Medium	Consistent	Direct	Precise	High	No difference
	Admissions up to day 7	5	1530	Low	Consistent	Direct	Imprecise	Moderate	No difference
	Clinical score: 60 minutes	4	1006	Low	Consistent	Direct	Precise	High	No difference
	Clinical score: 120 minutes	3	214	Medium	Consistent	Direct	Imprecise	Moderate	No difference
	Clinical score: 3 to 6 hours	2	808	Medium	Inconsistent	Direct	Precise	Moderate	No difference
	Clinical score: 12 to 24 hours	1	69	Medium	Unknown	Direct	Imprecise	Low	No difference
	Clinical score: 3 to 10 days	4	224	Medium	Inconsistent	Direct	Imprecise	Low	No difference
Inpatients/outpatients	Adverse events	5	1123	Low	Consistent	Direct	Precise	Moderate	No difference